Hypertensive type 2 diabetic patients had significantly higher left ventricular mass index (103 vs 89 g/m2) and nocturnal systolic blood pressure compared to essential hypertensive patients.
Cross-Sectional (n=176)
No
Does the presence of type 2 diabetes mellitus in hypertensive patients worsen left ventricular hypertrophy and diastolic function compared to essential hypertension alone?
Hyperglycemia and elevated nocturnal systolic blood pressure are independent predictors of increased left ventricular mass index in hypertensive patients with type 2 diabetes.
Absolute Event Rate: 103% vs 89%
p-value: p=<0.05
BACKGROUND: The aim of this study was to determine if hypertensive type 2 diabetic patients, when compared to patients with essential hypertension have an increased left ventricular mass index (LVMI) and a worse diastolic function, and if this fact would be related to 24-h pressoric levels changes. METHODS: Ninety-one hypertensive patients with type 2 diabetes mellitus (DM) (group-1 G1), 59 essential hypertensive patients (group-2 G2) and 26 healthy controls (group-3 G3) were submitted to 24-h Ambulatory Blood Pressure Monitoring (ABPM) and echocardiography (ECHO) with Doppler. We calculated an average of fasting blood glucose (AFBG) values of G1 from the previous 4.2 years and a glycemic control index (GCI) (percentual of FBG above 200 mg/dl). RESULTS: G1 and G2 did not differ on average of diurnal systolic and diastolic BP. However, G1 presented worse diastolic function and a higher average of nocturnal systolic BP (NSBP) and LVMI (NSBP = 132 +/- 18 vs 124 +/- 14 mmHg; P or =140 mmHg showed a higher risk of LVH. Diabetics with NSBP> or =140 mmHg and AFBG>165 mg/dl showed an additional risk of LVH (P < 0.05; odds ratio = 11). In multivariate regression, both GCI and NSBP were independent predictors of LVMI in G1. CONCLUSION: This study suggests that hyperglycemia and higher NSBP levels should be responsible for an increased prevalence of LVH in hypertensive patients with Type 2 DM.
Felício et al. (Tue,) conducted a cross-sectional in Hypertensive type 2 diabetes mellitus (n=176). Type 2 diabetes mellitus vs. Essential hypertension was evaluated on Left ventricular mass index (LVMI) (p=<0.05). Hypertensive type 2 diabetic patients had significantly higher left ventricular mass index (103 vs 89 g/m2) and nocturnal systolic blood pressure compared to essential hypertensive patients.