Capillary rarefaction in essential hypertension was associated with abnormal cardiovascular reactivity and exercise-induced rheological abnormalities compared to normotensive controls (P<0.05).
Case-Control (n=81)
Does capillary rarefaction affect cardiovascular reactivity and microcirculatory functioning during exercise in men with essential hypertension?
A reduced microvascular network in essential hypertension contributes to abnormal cardiovascular reactivity and exercise-induced rheological abnormalities.
p-value: p=< 0.05
OBJECTIVE: To determine the effects of capillary rarefaction on cardiovascular reactivity and microcirculatory functioning in essential hypertension. DESIGN: Hypertension is associated with abnormal cardiovascular reactivity and increased vasoconstriction. Capillary rarefaction amplifies these abnormalities, which modify microcirculatory hemodynamics. Hence this study of the hemorheological pattern and the veno-arteriolar reflex in hypertensive patients and normotensive control subjects. METHODS: Sixty-one men with never-treated essential hypertension and capillary rarefaction ( or = 73 capillaries per field. Abnormal responses to exercise worsened as capillaries were more rarefied. At recovery, hemorheological parameters in hypertensives with 65-72 capillaries per field returned to baseline, remaining significantly (P < 0.05) different to control values. Variations in the hemorheological pattern in hypertensives with < 64 capillary per field persisted at recovery. The veno-arteriolar reflex followed the same pattern. CONCLUSION: A reduced microvascular network may contribute to abnormal cardiovascular reactivity and to exercise-induced rheological abnormalities in hypertension.
Ciuffetti et al. (Mon,) conducted a case-control in Essential hypertension (n=81). Capillary rarefaction in essential hypertension vs. Normotensive controls was evaluated on Hemorheological pattern and veno-arteriolar reflex during exercise and recovery (p=< 0.05). Capillary rarefaction in essential hypertension was associated with abnormal cardiovascular reactivity and exercise-induced rheological abnormalities compared to normotensive controls (P<0.05).