A digital lifestyle management program reduced metabolic syndrome prevalence to 66.7% compared to 85.5% with standard of care at 90 days in adults with type 2 diabetes.
RCT (n=149)
Does personalized digital lifestyle coaching added to standard of care improve metabolic syndrome scores and metabolic age in adults with type 2 diabetes?
A digital lifestyle coaching program added to standard of care significantly improved metabolic syndrome prevalence, metabolic age, and glycemic control in adults with type 2 diabetes over 3 months.
Absolute Event Rate: 66.7% vs 85.5%
Introduction and Objective: Metabolic syndrome (MetS) clusters led to abnormalities accelerating metabolic aging. This 3-month randomized controlled trial compared the outcomes of MetS score and BCA-derived metabolic age through Sugarfit's Digital lifestyle management program versus standard of care (SOC). Methods: This trial enrolled 149 T2D adults: Test (personalized lifestyle coaching + SOC, n=87) vs Control (SOC alone, n=62). MetS score was assessed per IDF criteria with South Asian-specific cutoffs using waist circumference to define central obesity as a key factor. HbA1c, fasting blood sugar (FBS), weight, blood pressure (BP), triglyceride (TG), and high-density lipoprotein (HDL) were assessed at baseline and 90 days to evaluate lifestyle-based intervention’s impact on glycemic and anthropometric outcomes. Results: MetS prevalence in TG was 71 and CG was 52. At 90 days, the TG showed clear metabolic improvements where the prevalence was decreased to 58 participants, all MetS score combinations declined (BP/FBS: 17.74%, BP/TG: 14.52%, BP/HDL: 16.13%, TG/FBS: 14.52%, TG/HDL: 14.52%, FBS/HDL: 9.68%), metabolic age remained stable (55.94 → 55.91 years), and HbA1c (9.49±1.87→7.84±1.30%), FBS (162.22±56.14→140.97±52.54 mg/dL), weight (75.85±12.86→74.32±12.96 kg) improved. In contrast, MetS prevalence in CG increased to 53 participants with minimal changes in MetS score components, increasing metabolic age (58.60→60.97 years), and rising HbA1c/FBS with negligible anthropometric changes. Conclusion: Digital lifecoach-led personalized guidance in lifestyle management resulted in improved metabolic health, with notable reductions in MetS prevalence and scores. Improvements in glycemia and anthropometry compared with minimal or adverse changes in SOC. Long-term studies on similar platforms and care methods will further support the need for virtual, personalized, precision care in managing metabolic syndrome and its associated complications. Disclosure C.G. Mehra: None. A.M. Raymond: None. A. Sequeira: None. J. Joseline: None. S. Kumar: None.
MEHRA et al. (Fri,) conducted a rct in Type 2 Diabetes and Metabolic Syndrome (n=149). Sugarfit's Digital lifestyle management program vs. Standard of care was evaluated on Metabolic syndrome prevalence at 90 days. A digital lifestyle management program reduced metabolic syndrome prevalence to 66.7% compared to 85.5% with standard of care at 90 days in adults with type 2 diabetes.