Lower estimated glucose disposal rate (1st vs 3rd tertile) was significantly associated with high carotid plaque score in patients with type 2 diabetes (OR 1.99; 95% CI 1.46-2.71; p<0.001).
Cross-Sectional (n=1,242)
Is lower estimated glucose disposal rate associated with high carotid plaque score in individuals with type 2 diabetes?
Lower estimated glucose disposal rate is significantly associated with a higher prevalence of carotid plaque in patients with type 2 diabetes, suggesting its potential utility as a surrogate marker for early atherosclerosis.
Odds Ratio: 1.99 (95% CI 1.46–2.71)
Absolute Event Rate: 51.9% vs 33.2%
p-value: p=< 0.001
Introduction and Objective: Recent studies reported the associations of estimated glucose disposal rate (eGDR) with fatty liver disease, cardiovascular disease, and mortality. This study investigated whether eGDR was associated with carotid plaque score (PS) in individuals with type 2 diabetes (T2DM). Methods: A total of 1,242 subjects with T2DM were enrolled. The eGDR was calculated using the formula: 21.16 - 0.09 x waist circumference (WC, cm] - 3.41 x hypertension (yes=1/n=0) - 0.55 x HbA1c (%). All participants were categorized into three groups by the sex-specific eGDR tertile. Carotid PS was ranged from 0 to 12 and high PS was defined as ≥ 3. Results: Subjects with high PS were more likely to be old and male and had higher diabetes duration (DD), hypertension, systolic blood pressure (SBP), HOMA-IR, and serum creatinine (Cr), but lower body mass index (BMI), diastolic BP (DBP), HDL cholesterol, estimated glomerular filtration rate (eGFR) than those without high PS. Participants in the 1st eGDR tertile group were older and had higher DD, BMI, WC, SBP, fasting blood glucose (FBG), HOMA-IR, HbA1c, triglycerides (TG), C-reactive protein (CRP), Cr, and PS, but lower HDL cholesterol and eGFR compared to those in the 3rd tertile group. The prevalence of high PS was gradually increased with decreasing the sex-specific eGDR tertile (3rd vs. 2nd vs. 1st = 33.2% vs. 49.8% vs. 51.9%, p 0.001). The odds ratios (ORs) and 95% confidence intervals (CIs) for the presence of high PS after adjusted for age and sex, were 1.70 (1.25 - 2.32, p 0.001) in the 2nd and 1.99 (1.46 - 2.71, p 0.001) in the 1st eGDR tertile groups. The ORs and 95% CIs were remained significant in the 2nd and 1st tertile groups after further adjusted for DD, BMI, SBP, CRP, HDL cholesterol, TG, FBG, HOMA-IR, eGFR. Conclusion: Lower eGDR was significantly associated with high PS independent of multiple risk factors. Our results suggested that measuring eGDR may be a useful surrogate marker for the detection of early atherosclerosis in patients with T2DM. Disclosure J. Shin: None.
Jang Yel Shin (Fri,) conducted a cross-sectional in Type 2 diabetes (n=1,242). Low estimated glucose disposal rate (1st tertile) vs. High estimated glucose disposal rate (3rd tertile) was evaluated on Presence of high carotid plaque score (≥ 3) (OR 1.99, 95% CI 1.46 - 2.71, p=< 0.001). Lower estimated glucose disposal rate (1st vs 3rd tertile) was significantly associated with high carotid plaque score in patients with type 2 diabetes (OR 1.99; 95% CI 1.46-2.71; p<0.001).