Recent advances in synthetic organic electrochemistry using flow systems

The recent resurgence of electrochemical methods in organic synthesis has also boosted the interest in the use of flow electrolysis cells. Flow electrolyzers are essential tools for the scale up of electrolysis processes due to their high electrode surface area to reactor volume ratio, which only depends on the interelectrode gap regardless of the reactor size. Recent literature on the topic reveals that flow electrolysis cell are a very common tool on a lab scale to provide gram amounts of material, often enabling lower cell voltages and decrease amounts of supporting electrolyte needed for the reaction. Scale-up of electrochemical processes to multi-100 g and kilogram amounts has been demonstrated both using numbering up and sizing up strategies.