Why the study?
Existing models of excitation-contraction coupling depend on dyad stability, but dyadic motility had never been studied.
Population
Dissociated adult mouse ventricular myocytes
Authors
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Challenges static models of dyadic junctions in rodent myocytes; leaves open relevance to human EC coupling and disease.
Demonstrates that the junctional sarcoplasmic reticulum in adult ventricular myocytes is highly dynamic, challenging the traditional view of it as an immobile structure.
Drum et al. (2020) studied this question.