Key points are not available for this paper at this time.
OBJECTIVE: To investigate the effect of berberine (BBR) on intestinal barrier function in nonalcoholic fat liver disease (NAFLD) in rats. MATERIALS AND METHODS: Rats were divided into three groups: normal diet group (control group CON group), high-fat diet feeding group (HFD group), and HFD with BBR group. After 8 weeks of HFD feeding, rats in the BBR group were given BBR intragastrically at a dose of 150 mg/kg daily for 4 weeks. The same volume of normal saline was given to the CON and HFD groups. Liver index was detected, and Sudan black B staining was used to study fatty degeneration, also the expression level of occluding and intestinal flora was analyzed. RESULTS: and upregulate the level of bacteroides. CONCLUSION: BBR provides significant protection in NAFLD through ameliorating intestinal barrier function. SUMMARY: BBR: Berberine, NAFLD: Nonalcoholic fat liver disease, ALT: Alanine transaminase, AST: Aspartate aminotransferase, TG: Triglyceride, I-FABP: Intestinal-fatty acid-binding protein, IBD: Inflammatory bowel disease.
Li et al. (Sun,) studied this question.