May 8, 2020Open Access

Long-noncoding RNA MALAT1 sponges microRNA-92a-3p to inhibit doxorubicin-induced cardiac senescence by targeting ATG4a

Structured PICO

Do exosomes derived from hypoxia-preconditioned MSCs prevent doxorubicin-induced cardiac senescence in human iPSC-derived cardiomyocytes?

Population

Human-induced pluripotent stem cell-derived cardiomyocytes and human adipose-derived mesenchymal stem cells (MSCs) treated with doxorubicin (0.5 μM for 24 h) to model cardiac injury

Intervention

Exosomes derived from hypoxia-preconditioned MSCs (exosomeHypoxia)

Comparator

Exosomes derived from MSCs without any treatment (exosome) or untreated cardiomyocytes

Outcome

Doxorubicin-induced cellular senescence (measured by cell cycle distribution, p53 and p21 expression, and SA-β-gal staining)surrogate

Exosomes from hypoxia-preconditioned MSCs attenuate doxorubicin-induced cardiac senescence via the lncRNA-MALAT1/miR-92a-3p/ATG4a pathway, suggesting a potential therapeutic target for chemotherapy-induced cardiomyopathy.

Abstract

may serve as a potential therapeutic target against DIC.

AI에게 질문

Bookmark

View Full Paper