Cover Picture: Nanobody–chlorin e6 conjugate for Nectin‐4‐mediated tumor targeting and enhanced photodynamic therapy (View 3/2026)

Key Points

• The research aims to enhance photodynamic therapy (PDT) by using a nanobody conjugated to a photosensitizer for targeted tumor treatment.
• Conjugation of a nanobody to a photosensitizer to enhance tumor specificity.
• Assessment of the efficacy of the nanobody–photosensitizer conjugate in targeting Nectin-4.
• Evaluation of side effects related to nonspecific photosensitivity.
• Improved efficacy of PDT was observed with the nanobody–photosensitizer conjugate.
• Significant reduction in nonspecific photosensitivity-related side effects was reported.
• Enhanced aqueous solubility of the photosensitizer facilitated its accumulation in tumors.