Retrospective analysis shows diverse characteristics and prognosis in pediatric intracranial malignant germ cell tumors, suggesting the need for improved treatment approaches.
Key Points
This analysis aims to examine the clinical features and prognosis of pediatric intracranial malignant germ cell tumors at a single institution.
Conducted a retrospective analysis of clinical data from pediatric patients with primary iMGCTs at Beijing Children's Hospital (2017-2024).
Included comprehensive treatment involving chemotherapy, radiotherapy, and surgery under a multidisciplinary model.
In total, 36 patients were assessed, with germinomas showing 100% overall survival (OS) and 88.9% event-free survival (EFS) at 5 years.
Non-germinomatous germ cell tumor (NGGCT) patients had 91.3% OS and 69.2% EFS at 5 years; surgical resection led to higher EFS rates (88.2% vs 33.3%, P<0.05).
38.9% of survivors faced endocrine issues, indicating potential long-term effects of treatment.