A higher number of chronic diseases was associated with increased odds of dementia (OR 1.22; 95% CI 1.11-1.33), Alzheimer's disease, vascular dementia, and non-amnestic MCI in older adults.
Observational (n=5,432)
Is multimorbidity burden associated with cognitive impairment, dementia, and Alzheimer's disease plasma biomarkers in older adults?
Higher multimorbidity burden and specific disease clusters are associated with increased risk of dementia subtypes and elevated Alzheimer's disease plasma biomarkers in older adults.
Odds Ratio: 1.22 (95% CI 1.11–1.33)
INTRODUCTION: To examine the burden and clusters of multimorbidity in association with mild cognitive impairment (MCI), dementia, and Alzheimer's disease (AD)-related plasma biomarkers among older adults. METHODS: This population-based study included 5432 participants (age ≥60 years); of these, plasma amyloid beta (Aβ), total tau, and neurofilament light chain (NfL) were measured in a subsample (n = 1412). We used hierarchical clustering to generate five multimorbidity clusters from 23 chronic diseases. We diagnosed dementia and MCI following international criteria. Data were analyzed using logistic and linear regression models. RESULTS: The number of chronic diseases was associated with dementia (multivariable-adjusted odds ratio = 1.22; 95% confidence interval CI = 1.11 to 1.33), AD (1.13; 1.01 to 1.26), vascular dementia (VaD) (1.44; 1.25 to 1.64), and non-amnestic MCI (1.25; 1.13 to 1.37). Metabolic cluster was associated with VaD and non-amnestic MCI, whereas degenerative ocular cluster was associated with AD (p < 0.05). The number of chronic diseases was associated with increased plasma Aβ and NfL (p < 0.05). DISCUSSION: Multimorbidity burden and clusters are differentially associated with subtypes of dementia and MCI and AD-related plasma biomarkers in older adults. HIGHLIGHTS: We used hierarchical clustering to generate five clusters of multimorbidity. The presence and load of multimorbidity were associated with dementia and mild cognitive impairment. Multimorbidity clusters were differentially associated with subtypes of dementia and Alzheimer's disease plasma biomarkers.
Ren et al. (Sat,) conducted a observational in Multimorbidity, cognitive impairment, and dementia (n=5,432). Multimorbidity burden (number of chronic diseases) was evaluated on Dementia (OR 1.22, 95% CI 1.11 to 1.33). A higher number of chronic diseases was associated with increased odds of dementia (OR 1.22; 95% CI 1.11-1.33), Alzheimer's disease, vascular dementia, and non-amnestic MCI in older adults.