Decoding the dynamic extracellular matrix in cancer— 3D models and bioscaffolds rewire the rules of tumor progression

Key Points

• This research aims to understand how the extracellular matrix influences cancer progression and cellular behavior.
• Utilized three-dimensional cancer models to simulate in vivo tumor microenvironments.
• Engineered bioscaffolds to mimic physiological conditions for accurate tumor modeling.
• Explored the impact of matrix remodeling on cellular dynamics and therapeutic approaches.
• Three-dimensional models demonstrated enhanced reflection of real tumor behavior compared to traditional models.
• Bioscaffolds supported effective mimicking of the tumor microenvironment, improving preclinical research capabilities.
• Matrix-based platforms provided a more accurate basis for therapeutic development in cancer research.