Oral administration of 80 mg of propranolol or sotalol resulted in maternal concentrations approximately four times and two times higher than umbilical concentrations, respectively.
What is the transplacental passage of propranolol and sotalol in parturients undergoing cesarean section?
Both propranolol and sotalol cross the human placenta, with sotalol demonstrating a higher umbilical-to-maternal concentration ratio than propranolol.
Eighty milligrams of propranolol or sotalol was administered orally to two groups of 8 parturients who were to undergo elective cesarean section. This was performed 3 hours after drug administration. The transplacental passage of both drugs was registered in each patient. The maternal concentration of propranolol was approximately four times that in the umbilical circulation, while the sotalol level in maternal circulation was twice that in the umbilical circulation. The administration of beta-adrenoceptor antagonists caused a significant decrease in maternal plasma renin activity. After these doses of beta blockers, no difference in the plasma renin activity was found in the umbilical circulation, when compared with the previous normal values at cesarean section.
Erkkola et al. (Fri,) conducted a other in Pregnancy (undergoing elective cesarean section) (n=16). Propranolol or sotalol was evaluated on Transplacental passage (maternal vs umbilical concentration). Oral administration of 80 mg of propranolol or sotalol resulted in maternal concentrations approximately four times and two times higher than umbilical concentrations, respectively.
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