The tPA -7351 TT genotype showed a positive association with lacunar stroke in an Australian population, though this finding was based on subgroup analysis and remains hypothesis generating.
Does the tPA -7351 TT genotype associate with lacunar stroke in an Australian population?
The tPA -7351 TT genotype has a positive, hypothesis-generating association with lacunar stroke in an Australian population.
We thank Armstrong and colleagues for acknowledging the importance of the original study, which found a positive association between the tPA -7351 TT genotype and lacunar stroke in an Australian population. As we concluded in the article, this association was made after subgroup analysis and was thus interpreted as hypothesis generating. We agree that confirmation in a larger, well-designed study is critical. It is important to reiterate that the tPA 7351 C/T polymorphism possesses a plausible biological reason to cause cerebral lacunar infarction,
Boulanger et al. (2006) conducted a letter in lacunar stroke. tPA -7351 TT genotype was evaluated on lacunar stroke. The tPA -7351 TT genotype showed a positive association with lacunar stroke in an Australian population, though this finding was based on subgroup analysis and remains hypothesis generating.