Why the study?
The association of the combined triglyceride glucose index and Chinese visceral adiposity index (TyG-CVAI) with new-onset CVD risk in the general population was unclear.
Does a higher TyG-CVAI predict an increased risk of new-onset cardiovascular disease in middle-aged and older Chinese adults?
Population
7977 participants in the CHARLS cohort without CVD at baseline
Comparison
TyG-CVAI quartiles
Design
Prospective cohort study
Key result
A higher TyG-CVAI was associated with an increased risk of new-onset cardiovascular disease, with the highest quartile having a significantly higher risk than the lowest (HR 1.64; 95% CI 1.35-2.00).
Authors
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May aid CVD risk prediction in middle-aged Chinese adults; leaves open incremental value over standard markers pending validation.
Cohort (n=7,977)
Yes
Does a higher TyG-CVAI predict an increased risk of new-onset cardiovascular disease in middle-aged and older Chinese adults?
Hazard Ratio: 1.64 (95% CI 1.35–2)
p-value: p=<0.001
The TyG-CVAI is a strong, nonlinear predictor of new-onset cardiovascular disease in middle-aged and older Chinese adults, outperforming its individual components.
Zheng et al. (2026) conducted a cohort in new-onset cardiovascular disease (n=7,977). TyG-CVAI vs. Lowest quartile (Q1) of TyG-CVAI was evaluated on incidence of new-onset CVD (HR 1.64, 95% CI 1.35-2.00, p=<0.001). A higher TyG-CVAI was associated with an increased risk of new-onset cardiovascular disease, with the highest quartile having a significantly higher risk than the lowest (HR 1.64; 95% CI 1.35-2.00).