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Multiple point stimulation (MPS) is described as a method of estimating the numbers of motor units in the median innervated thenar muscles of young and older control subjects. Stimulation at multiple sites along the course of the median nerve was employed to collect a sample of the lowest threshold, all-or-nothing surface-recorded motor unit action potentials (S-MUAPs). The average, negative peak area, and peak-to-peak amplitude of the sample of S-MUAPs was determined and divided into the corresponding value for the maximal compound muscle action potential to derive the motor unit estimate (MUE). In 37 trials from 17 younger subjects (20-40 years), the mean MUE was 288 +/- 95 SD based on negative peak area and, in 33 trials from 20 older subjects, mean values were 139 +/- 68. In 23 young and older subjects, MPS was performed on at least two occasions and the MUEs were found to be highly correlated (r = 0.88).
Doherty et al. (Thu,) studied this question.