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The urinary excretion of kallikrein was examined in rats whose mineralocorticoid level was increased by the administration of deoxycorticosterone or a low-sodium diet and decreased by adrenalectomy. Administration of deoxycorticosterone by injection or by subcutaneous implantation of pellets resulted in a threefold increase in kallikrein excretion after 10-30 days ( P <0.01). Low-sodium intake produced a twofold increase in kallikrein excretion after 2 and 4 weeks ( P <0.01). Urine volume and blood pressure were normal and unchanged throughout the study. Sodium excretion was unaltered by deoxycorticosterone but was essentially zero during low-sodium intake. Adrenalectomized rats excreted less than half the kallikrein of shamoperated control rats ( P <0.01). These data show a direct relationship between mineralocorticoids and kallikrein excretion and suggest that mineralocorticoids are a primary factor regulating the urinary excretion of kallikrein in rats.
Geller et al. (1972) studied this question.