The Spectrum of Radiographic Findings in Antibiotic-Related Pseudomembranous Colitis

The radiographic findings in pseudomembranous colitis related to antibiotic therapy have previously been considered nonspecific and indistinguishable from those seen in other acute ulcerating colitides. A review of 9 such patients evaluated over a period of 6 months suggests a range of radiographic abnormalities including, in severe cases, an appearance which is strongly suspicious of this condition and may be diagnostic. While proctosigmoidoscopy is the preferable diagnostic tool, the barium enema will frequently precede it, enabling the radiologist to suggest the diagnosis. Early recognition is important, as this condition carries a significant morbidity unless the offending antibiotic is discontinued.