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BACKGROUND: Apart from the rare association with type I multiple endocrine neoplasia (MEN-1), familial types of prolactinoma have not been reported. PATIENTS AND MEASUREMENTS: Eight hyperprolactinaemic patients in four families and 18 of their first and second-degree relatives (parents, children and grandchildren) were examined. Hormone levels were measured, as well as other biochemical parameters. RESULTS: Prolactinoma was diagnosed in more than one member of each of the four families. CONCLUSION: Familial prolactinoma is a distinct entity which is probably due to a genetic mutation promoting lactotroph proliferation.
Berezin et al. (1995) studied this question.