Multi-Omics Analysis Identifies Immune Regulatory Networks in Sepsis-Associated Liver Injury: Experimental Validation and Clinical Relevance

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Discussion

Multi-Omics analysis reveals immune-related genes in sepsis-induced liver injury, suggesting novel therapeutic targets.

T cell-related biomarkers were identified, offering potential therapeutic targets in sepsis-induced liver injury.
Analysis indicated a significant elevation in IL-1β and lactate levels, confirming inflammatory processes during sepsis.
Assessment involved murine models and bioinformatics, integrating functional enrichment and protein interaction networks for insights.
Findings underscore the immune regulatory networks and cytokine interactions, advancing understanding of sepsis-related liver dysfunction.

Hong et al. (2025) studied this question.

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