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September 10, 2025Journal of Bronchology & Interventional Pulmonology

Safety and Diagnostic Yield of Transbronchial Cryobiopsy by Flexible Bronchoscopy Under Conscious Sedation Without Intubation in Diffuse Parenchymal Lung Disease

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Authors

YCYifan ChenYLYang LiuHZHao Zhu

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Overview

Observational analysis shows good diagnosis yield and safety in patients with DPLD, suggesting TBCB can be performed without intubation.

Key Points

  • Transbronchial cryobiopsy achieved a diagnostic yield of 70.3% in DPLD patients under conscious sedation, indicating its effectiveness.
  • A total of 36 out of 37 patients received adequate pathologic specimens, with an average specimen diameter of 4.28 mm.
  • Pneumothorax occurred in 16.2% of cases; however, there were no severe complications requiring surgery or embolization.
  • This method highlights the potential for safely diagnosing DPLD in patients unable to tolerate general anesthesia.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c18bf99b7b07f3a061421chttps://doi.org/10.1097/lbr.0000000000001023
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