Motivation: Mild traumatic brain injury (mTBI) often leads to long-term physical, cognitive, and emotional challenges. Resting-state fMRI studies have shown functional brain changes in mTBI, but a comprehensive understanding of brain alterations remains limited. Goal(s): This study aims to examine brain entropy (BEN) in mTBI patients over time, exploring its potential association with neurocognition and recovery. Approach: Using longitudinal rs-fMRI data, we assessed BEN —a novel metric linked to brain function and pathology —in mTBI patients, analyzing changes from the acute to chronic phases. Results: Our preliminary results suggest increased BEN during the acute phase of mTBI, with normalization as cognitive function improves over time. Impact: This study positions brain entropy (BEN) as a potential biomarker for tracking recovery in mTBI. BEN's sensitivity to acute functional changes and its normalization with cognitive improvement could enhance diagnostic precision and inform therapeutic interventions in mTBI management.
Jiang et al. (Tue,) studied this question.
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