Androgenetic alopecia (AGA) is a common form of hair loss affecting men, characterized by progressive miniaturization of hair follicles. Plateletrich plasma (PRP) and topical Minoxidil 5% are widely used treatment modalities, but their comparative efficacy remains a topic of investigation. This study aims to evaluate and compare the effectiveness of PRP therapy and Minoxidil 5% in treating AGA. This prospective study included 28 male patients diagnosed with AGA, divided equally into two groups: Group-P(PRPtherapy) and Group-M (Minoxidil 5%). Baseline demographic characteristics, family history, and clinical parameters such as age of onset, Norwood-Hamilton classification, hair density, hair thickness, and hair pull test results were recorded. PRP was prepared and injected in Group-P, while Group-M applied Minoxidil 5% twice daily. Patients were followed up at baseline, 3 months, and 6 months, and outcomes were assessed using hair density, hair thickness, hair pull test, bald spot reduction, hair growth response, effectiveness in slowing hair loss, and overall patient satisfaction. At 6 months, Group-P demonstrated significant improvement in hair density (120.47 ± 6.34 hairs/cm²) and hair thickness (53.88 ± 4.26 µm) compared to Group-M (105.53 ± 5.95 hairs/cm², 46.33 ± 4.17 µm, p < 0.0001). PRP therapy showed a better response in bald spot reduction and hair growth, with 35.7% of PRP patients rating it as very effective versus 14.3% in the Minoxidil group. Patient satisfaction was significantly higher in Group-P, particularly for top-of-head coverage (p = 0.0493).
Chauhan et al. (Mon,) studied this question.