Time-Dependent Diffusion MRI for the Breast to Differentiate between Benign and Malignant Lesions

Defining the nature of benign and malignant breast tumors is essential to reduce unnecessary biopsies of benign tumors. Magnetic resonance imaging (MRI) is the most sensitive imaging modality for evaluating breast carcinoma lesions, but its specificity is relatively low. This study investigated the significance of the parameters for the differential diagnosis of mammary mass using time-dependent diffusion MRI. Results showed significant cell size differences between benign and malignant space-occupying lesions, with high accuracy (85.7%), specificity (83.3%), sensitivity (87.5%) and AUC (0.823). This provides a new direction for noninvasively differentiating benign and malignant lesions of the mammary gland.