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Functional QSM (fQSM) detects changes in blood oxygenation in response to neuronal activation, providing complementary information to conventional magnitude-based fMRI. For standard structural gradient-echo QSM, multi-echo (ME) acquisitions are more accurate than single-echoes. Preliminary work suggests this holds for ME-EPI. Previous fQSM studies used single-echo EPI with physiological noise correction but with ME-EPI, we observed fQSM activations in the visual cortex with a visual stimulus without physiological noise correction. ME and single-echo EPI fQSM were compared, showing that ME-EPI might be preferable. fQSM activations were weaker (maximum T-score=4 compared to 10 in fMRI) and more localised than fMRI, as expected.
Nassar et al. (Wed,) studied this question.
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