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You have accessJournal of UrologyBladder Cancer: Invasive IV (PD38)1 May 2024PD38-06 EFFECT OF MAXIMAL TRANSURETHRAL RESECTION PRIOR TO NEOADJUVANT CHEMOTHERAPY ON ONCOLOGICAL OUTCOMES IN PATIENTS WHO UNDERGO RADICAL CYSTECTOMY: A MULTICENTER RETROSPECTIVE STUDY Naoki Fujita, Toshikazu Tanaka, Shogo Hosogoe, Noritaka Ishii, Masaki Momota, Hiroyuki Ito, Ikuya Iwabuchi, Takahiro Yoneyama, Yasuhiro Hashimoto, Chikara Ohyama, and Shingo Hatakeyama Naoki FujitaNaoki Fujita , Toshikazu TanakaToshikazu Tanaka , Shogo HosogoeShogo Hosogoe , Noritaka IshiiNoritaka Ishii , Masaki MomotaMasaki Momota , Hiroyuki ItoHiroyuki Ito , Ikuya IwabuchiIkuya Iwabuchi , Takahiro YoneyamaTakahiro Yoneyama , Yasuhiro HashimotoYasuhiro Hashimoto , Chikara OhyamaChikara Ohyama , and Shingo HatakeyamaShingo Hatakeyama View All Author Informationhttps://doi.org/10.1097/01.JU.0001009424.64728.0c.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Bladder-preserving trimodal therapy involving the combination of maximal transurethral resection (TUR) and combined chemoradiation therapy is recognized as a promising alternative treatment option for muscle-invasive bladder cancer (MIBC). However, the effect of maximal TUR (visually complete resection of the tumor) prior to neoadjuvant chemotherapy (NAC) on oncological outcomes in patients who undergo radical cystectomy (RC) remains unclear. METHODS: This multi-institutional retrospective study included 550 patients with MIBC who received 2–4 cycles of NAC followed by RC. Patients were divided into two groups: patients who underwent maximal TUR prior to NAC (maximal TUR group) and patients who did not (control group). The downstage and ypT0 rates were compared between the two groups. Multivariable Cox-proportional hazards regression analysis was performed to evaluate the effect of maximal TUR on recurrence-free survival (RFS). RESULTS: The median age follow-up period were 69 years and 54 months, respectively. The downstage and ypT0 rates in the maximal TUR group were significantly higher than those in the control group (Figures 1 and 2, respectively). RFS in the maximal TUR group was significantly longer than that in the control group (Figure 3). After adjustment for confounding variables, maximal TUR was significantly associated with prolonged RFS (Table 1). CONCLUSIONS: The maximal TUR prior to NAC might contribute to improving oncological outcomes in patients who undergo RC. Download PPTDownload PPTDownload PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e808 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Naoki Fujita More articles by this author Toshikazu Tanaka More articles by this author Shogo Hosogoe More articles by this author Noritaka Ishii More articles by this author Masaki Momota More articles by this author Hiroyuki Ito More articles by this author Ikuya Iwabuchi More articles by this author Takahiro Yoneyama More articles by this author Yasuhiro Hashimoto More articles by this author Chikara Ohyama More articles by this author Shingo Hatakeyama More articles by this author Expand All Advertisement PDF downloadLoading ...
Fujita et al. (Mon,) studied this question.