Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persistent Hyperparathyroidism: A Retrospective Study

Background:Secondary hyperparathyroidism and coronary calcifications are common complications in chronic kidney disease.However, the relation between coronary calcium score (CCS) and persistent hyperparathyroidism (pHPT) after kidney transplantation (KT) remains unknown. Material/Methods:This was a single-center retrospective study of KT candidates from January 2017 to May 2020.We collected patients' demographics, cardiovascular (CV) risk factors, and the findings of pre-KT CV imaging.We also collected parathyroid hormone (PTH) values before KT, at 1-6 months, 6-12 months, and 12-24 months after KT.We defined pHPT as PTH ³25.5 pmol/L after 12 months post-KT. Results:A total of 111 KT recipients (KTRs) with a mean age of 50.4 years were included, of which 62.2% were men and 77.5% were living-donor KTRs.Dialysis modality used before KT was peritoneal dialysis in 9.9% and hemodialysis in 82.9%.Dialysis vintage was 3±2.9 years.The prevalence of pHPT was 24.3% (n=27), and the prevalence of severe coronary calcifications (CCS >400 Agatston units) was 19.8% (n=22).PTH values at baseline, 1-6 months, 6-12 months, and 12-24 months were not different among between CCS >400 or CCS 400 was independently associated with pHPT after transplant (aOR=18.8,P=0.012). Conclusions:Severe CCS on pre-KT cardiac assessment is associated with pHPT after KT.