Abstract Acne vulgaris is a common inflammatory skin disorder worldwide. Papaya leaves are rich in bioactive compounds with antibacterial effects. This study aimed to develop papaya leaf essential oil (PLEO) nanoemulgel with anti‐acne properties. Parameters, such as sonication duration (1–3 min), essential oil concentration (5–9% w/w), surfactant concentration (4–8% w/w), and hydrogel concentration (0.4–0.8% w/w), were optimized to obtain a nanoemulgel with the smallest droplet size and a narrow size distribution. Under the optimum conditions (2 min of sonication, 7% PLEO, 8% Tween 80, and 0.4% Carbopol 940), a nanoemulgel with a Sauter mean diameter (SMD) of 114 nm and a span value of 1.34 was obtained. Compared with the pure oil, the PLEO nanoemulgel exhibited larger zones of inhibition against acne‐causing bacteria. This study highlights the potential of PLEO nanoemulgel as a cosmeceutical ingredient for acne management.
Yap et al. (Sat,) studied this question.
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