What is the clinical evidence from this study?

Study design: Cohort. Population: Ischemic stroke (n=210). Intervention: Elevated Lipoprotein(a) levels vs. Lower Lipoprotein(a) levels. Primary outcome: Post-stroke composite cardiovascular events (stroke and MI) (OR 2.37, 95% CI 1.09-5.15, p=0.03).

What question did this study set out to answer?

This study investigates the association between lipoprotein(a) levels and cardiovascular events in stroke survivors.

February 2, 2026Stroke

Abstract TP138: Elevated lipoprotein (a) is associated with occurrence of cardiovascular events in stroke survivors

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Key result

Elevated Lp(a) ≥50 mg/dL is linked to ~137% higher post-stroke cardiovascular risk.

OR 2.37
95% CI 1.09-5.15
P=0.03
n=210

Why the study?

Do elevated Lipoprotein(a) levels increase the risk of recurrent stroke and cardiovascular events in ischemic stroke survivors?

Key Points

This study investigates the association between lipoprotein(a) levels and cardiovascular events in stroke survivors.
Retrospective cohort study of ischemic stroke patients with Lp(a) testing from 2017-2024.
Outcomes assessed include stroke recurrence, post-stroke myocardial infarction (MI), and composite cardiovascular events.
Lp(a) levels categorized into thresholds (≥30, ≥50, and ≥70 mg/dL).
Subgroup analyses conducted by ischemic stroke etiology.
Median Lp(a) level was 22.35 mg/dL among 210 patients.
Elevated Lp(a) ≥70 mg/dL associated with a higher incidence of recurrent strokes (IRR=1.55).
Elevated Lp(a) levels (≥50 and ≥70 mg/dL) linked to small vessel disease etiology.
Lp(a) ≥50 mg/dL significantly associated with the risk of post-stroke MI (OR=10.36).
Elevated Lp(a) predicts increased risk of composite cardiovascular events (OR=2.37).

Study Design

Type

Cohort (n=210)

Multicenter

Structured PICO

Do elevated Lipoprotein(a) levels increase the risk of recurrent stroke and cardiovascular events in ischemic stroke survivors?

Population

210 ischemic stroke survivors (mean age 52 years, 52% female) who underwent Lp(a) testing between 2017 and 2024 at a single academic center.

Exposure

Elevated Lipoprotein(a) levels (evaluated at thresholds of ≥30, ≥50, and ≥70 mg/dL)

Comparator

Lower Lipoprotein(a) levels (below the evaluated thresholds)

Outcome

Stroke recurrence, post-stroke MI, and composite cardiovascular events (stroke and MI)hard clinical

Main Result

Odds Ratio: 2.37 (95% CI 1.09–5.15)

p-value: p=0.03

Discussion

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Implication

Elevated Lipoprotein(a) levels (≥50 mg/dL) are significantly associated with an increased risk of recurrent stroke and post-stroke myocardial infarction in ischemic stroke survivors.

Cite This Study

Zhang et al. (2026) conducted a cohort in Ischemic stroke (n=210). Elevated Lipoprotein(a) levels vs. Lower Lipoprotein(a) levels was evaluated on Post-stroke composite cardiovascular events (stroke and MI) (OR 2.37, 95% CI 1.09-5.15, p=0.03). In ischemic stroke survivors, elevated Lp(a) ≥50 mg/dL was significantly associated with an increased risk of post-stroke composite cardiovascular events (OR 2.37; 95% CI 1.09-5.15; p=0.03).

synapsesocial.com/papers/6980fd18c1c9540dea80ed07 https://doi.org/10.1161/str.57.suppl_1.tp138

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Implication

Elevated Lipoprotein(a) levels (≥50 mg/dL) are significantly associated with an increased risk of recurrent stroke and post-stroke myocardial infarction in ischemic stroke survivors.

Abstract TP138: Elevated lipoprotein (a) is associated with occurrence of cardiovascular events in stroke survivors

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Abstract TP138: Elevated lipoprotein (a) is associated with occurrence of cardiovascular events in stroke survivors

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider