This preprint introduces the Microbial Integration Architecture Theory (MIAT), a conceptual framework proposing that host physiology is governed by microbe-driven architectural constraints rather than isolated cellular or molecular mechanisms. This version refines the original Microbial Integration Theory (MIT) into the Microbial Integration Architecture Theory (MIAT), clarifying its architectural and governance-based scope while preserving the original conceptual foundations. The revision strengthens the definition of microbial-driven physiological directionality and improves conceptual precision across the framework. MIAT integrates microbial metabolism, enzymatic cycling, extracellular matrix (ECM) biophysics, fascia-mediated signal distribution, immunometabolism, and psychophysiological regulation into a unified ecological model of physiological governance. The theory positions microbial ecosystems as the creators of biological initial conditions, regulators of enzymatic continuity, directors of regenerative or degenerative physiological directionality, and stabilizers of long-term systemic coherence. Within this framework, chronic disease is reframed not as primary cellular failure, but as prolonged governance under microbial–ECM–fascia collapse. MIAT provides a non-reductionist yet biologically testable architecture, generating falsifiable predictions for future research in regenerative biology, metabolic regulation, immunophysiology, and psychophysiological modulation.
Henny Hendiyani Irjanti (Fri,) studied this question.