This study demonstrates that prenatal arsenic exposure induces early molecular perturbations in the neonatal brain by altering competing endogenous RNA regulatory networks. More importantly, the integration of transcriptomic data with network-based analyses provides a systematic framework for elucidating the underlying mechanisms of developmental neurotoxicity, highlighting key signaling pathways associated with synaptic function and neuronal communication. This network-oriented approach offers mechanistic insights beyond single-gene analysis and facilitates the identification of critical regulatory processes involved in arsenic-induced neurodevelopmental effects.
Wang et al. (Sat,) studied this question.
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