Key result
VE/VCO2 slope ≤34 is linked to ~50% lower 10-year mortality in advanced ambulatory heart failure.
Why the study?
Do cardiopulmonary exercise testing parameters (VE/VCO2 and exercise oscillatory ventilation) improve risk stratification for heart transplantation referral in ambulatory heart failure patients with peak VO2 <12 mL/kg/min?
Cohort (n=1,218)
Do cardiopulmonary exercise testing parameters (VE/VCO2 and exercise oscillatory ventilation) improve risk stratification for heart transplantation referral in ambulatory heart failure patients with peak VO2 <12 mL/kg/min?
p-value: p=<0.01
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Current guideline criteria of peak VO2 <12 mL/kg/min alone may not reliably identify HF patients needing transplant referral; incorporating VE/VCO2 and exercise oscillatory ventilation provides better risk stratification.
Azar et al. (2026) conducted a cohort in Ambulatory heart failure (n=1,218). Peak VO2 <12 mL/kg/min vs. Heart transplantation recipients was evaluated on Composite of death, left ventricular assist device, or heart transplantation (p=<0.01). Ambulatory heart failure patients with peak VO2 <12 mL/kg/min had better survival than transplant recipients up to 2.7 years; VE/VCO2 ≤34 halved 10-year mortality risk (p<0.01).
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