Inflammation at the crossroads of reproduction: SIRI as a prognostic signature of female infertility in hybrid regression–machine learning models

Key Points

• This research investigates the connection between chronic systemic inflammation and female infertility, focusing on SIRI as a prognostic biomarker.
• Utilized hybrid regression and machine learning models to analyze data.
• Assessed the impact of inflammatory markers on fertility outcomes.
• Identified SIRI as a significant predictor for infertility risk.
• Conducted clinical evaluations to validate findings.
• Confirmed a strong association between chronic inflammation and infertility.
• Demonstrated that SIRI serves as a reliable biomarker for assessing infertility risk.
• Showed that machine learning models improved the accuracy of predictions related to infertility.