Dl-3-n-Butylphthalide Inhibits Ferroptosis and Attenuates Sepsis-Associated Acute Kidney Injury by Activating the Nrf2/HO-1 Pathway

Key Points

• The aim is to investigate the role of Dl-3-n-butylphthalide in protecting against sepsis-associated acute kidney injury through the Nrf2/HO-1 pathway.
• Evaluated the effects of NBP on ferroptosis in context of sepsis-associated acute kidney injury.
• Activated and analyzed the Nrf2/HO-1 pathway to assess its protective role.
• Conducted in vivo and/or in vitro experiments to measure kidney injury markers.
• NBP significantly inhibits ferroptosis associated with acute kidney injury.
• Activation of the Nrf2/HO-1 pathway is linked to reduced injury in kidney cells during sepsis.