What question did this study set out to answer?

This research aims to explore how distinct death receptor signaling pathways influence apoptosis in host cells affected by Eimeria tenella.

February 14, 2026Current Issues in Molecular BiologyOpen Access

Influence of Different Death Receptor Signaling Pathways on Apoptosis of Eimeria tenella Host Cells

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Authors

ZXZhiyong Xu XYXuanyao Yu JMJinyou Ma

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Overview

The study investigates how different death receptor pathways affect host cell apoptosis in chickens, suggesting implications for Eimeria tenella infections.

Key Points

This research aims to explore how distinct death receptor signaling pathways influence apoptosis in host cells affected by Eimeria tenella.
Utilized primary chicken embryo cecal epithelial cell culture
Employed gene silencing techniques
Conducted ELISA and apoptosis staining
Performed hematoxylin-eosin staining
Used quantitative real-time polymerase chain reaction (qRT-PCR)
Fas and TNFR1 mRNA expression levels in infected cells were significantly higher than controls during the study period
TRAIL mRNA expression in infected cells increased notably at later time points
FADD and Daxx gene expression, as well as caspase-8 activity, were lower in specific treatment groups compared to controls
TRADD expression varied significantly between treatment groups, affecting apoptosis rates
Overall, the study ranked the pro-apoptotic effects of pathways as Fas > TNFR1 > TRAIL.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/699011032ccff479cfe575ef https://doi.org/10.3390/cimb48020203

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February 14, 2026Current Issues in Molecular BiologyOpen Access

Influence of Different Death Receptor Signaling Pathways on Apoptosis of Eimeria tenella Host Cells

View Full Paper

Ask AI

Bookmark

Authors

ZXZhiyong Xu XYXuanyao Yu JMJinyou Ma

Discussion

Member takes

Overview

The study investigates how different death receptor pathways affect host cell apoptosis in chickens, suggesting implications for Eimeria tenella infections.

Key Points

This research aims to explore how distinct death receptor signaling pathways influence apoptosis in host cells affected by Eimeria tenella.
Utilized primary chicken embryo cecal epithelial cell culture
Employed gene silencing techniques
Conducted ELISA and apoptosis staining
Performed hematoxylin-eosin staining
Used quantitative real-time polymerase chain reaction (qRT-PCR)
Fas and TNFR1 mRNA expression levels in infected cells were significantly higher than controls during the study period
TRAIL mRNA expression in infected cells increased notably at later time points
FADD and Daxx gene expression, as well as caspase-8 activity, were lower in specific treatment groups compared to controls
TRADD expression varied significantly between treatment groups, affecting apoptosis rates
Overall, the study ranked the pro-apoptotic effects of pathways as Fas > TNFR1 > TRAIL.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/699011032ccff479cfe575ef https://doi.org/10.3390/cimb48020203

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