A mutation-aware proteomics approach for designing a multi-epitope vaccine against multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa

Multidrug resistance has become a common phenomenon leading to difficulty in infection control. No options are left to treat such infections after the emergence of colistin resistance. Therefore, this approach to developing multi-epitope therapeutic vaccines is very promising to face the challenge of infection control. This study is based on comparative pan-genomic and subtractive proteomic analyses of 30 proteomes, which provide a wider range of proteins to select multiple epitopes for effective vaccine.