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Oral mucositis secondary to datopotamab deruxtecan for advanced-stage cancer managed with cryotherapy after topical steroid failure | Synapse
March 3, 2026
Oral mucositis secondary to datopotamab deruxtecan for advanced-stage cancer managed with cryotherapy after topical steroid failure
PF
Paolo Junior Fantozzi
Policlinico Umberto I
SS
Stephen T. Sonis
JD
John P. Diaz
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Key Points
Oral mucositis was effectively managed using cryotherapy following failure of topical steroids.
The intervention demonstrates that cryotherapy can alleviate symptoms in cases where standard treatments fail.
Case analysis highlights the effectiveness of cryotherapy in mitigating the adverse effects of datopotamab deruxtecan.
Significant potential for improving patient comfort with this approach, though further studies are needed.
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Fantozzi et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75badc6e9836116a23789
https://doi.org/https://doi.org/10.1016/j.adaj.2025.11.015