“When is it late”? Optimal threshold for duration of untreated illness (DUI) to predict SSRI-treatment resistance in individuals with obsessive-compulsive disorder (OCD)

Key Points

• A duration of untreated illness over 3.5 years significantly lowers SSRI response rates in individuals with OCD.
• The study identifies forty-two months as a critical cutoff for predicting treatment resistance to SSRIs.
• This observational analysis suggests the importance of early intervention in treating obsessive-compulsive disorder effectively.
• Replicating findings in larger, multicentric samples is necessary to validate the predictive threshold established.