The position of 99mTc-HYNIC and the molecular design of the DARPin G3 constructs influence the selection of an imaging tracer to detect expression in HER2-expressing tumors

Key Points

• HER2 expression detection is improved by optimizing tracer position and molecular design.
• Geometric positioning of 99mTc-HYNIC significantly affects tracer efficacy in imaging.
• Observational analysis of imaging methods focusing on HER2-expressing tumors and molecular constructs.
• Findings suggest that strategic design changes in tracers can enhance selective tumor imaging.