Complementary roles of HMGB1 and PRDX4 in the pathophysiology of steroid-associated osteonecrosis of the femoral head: a histopathological and immunohistochemistry study

Key Points

• Steroid-associated osteonecrosis shows significant involvement of HMGB1 and PRDX4 in the underlying pathophysiology.
• Key findings indicate elevated levels of HMGB1 and PRDX4 in histopathological samples suggesting their roles in tissue damage.
• Assessment using immunohistochemistry across various samples demonstrates the distinct expressions of HMGB1 and PRDX4 in affected tissues.
• This implies further research on HMGB1 and PRDX4 is necessary to understand their combined influence in bone health.