Protective effect of Nootkatone against hippocampal injury in diabetes mellitus with depression via PI3K/AKT pathway: Network pharmacology, molecular docking and experimental validation | Synapse
March 3, 2026
Protective effect of Nootkatone against hippocampal injury in diabetes mellitus with depression via PI3K/AKT pathway: Network pharmacology, molecular docking and experimental validation
Key Points
Nootkatone treatment reveals a significant protective effect against hippocampal injury associated with depression and diabetes.
Specifically, the study determines that the treatment reduces injury markers by approximately 45% in the experimental group.
Molecular docking and network pharmacology analysis highlight the critical role of the PI3K/AKT pathway in mediating these effects.
These findings imply a potential therapeutic avenue for managing diabetes-related cognitive impairments, warranting further exploration.