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Examine toxicity and interaction pathways of alpha-hexylcinnamaldehyde and lilial in consumer products.

March 12, 2026Toxicology Mechanisms and Methods0 citations

Toxicological perspectives on potential mixture toxicity of alpha-hexylcinnamaldehyde and lilial in consumer products

KOKennlee OrolaChung-Ang University SMSung‐Hwan MoonKyungpook National University SSSeung Hee ShinChung-Ang University

Key Points

Examine toxicity and interaction pathways of alpha-hexylcinnamaldehyde and lilial in consumer products.
Synthesis of in vitro and in vivo data
Analysis of mechanistic pathways
Evaluation of regulatory aspects
Identified gaps in current mixture toxicity research
Outlined interaction pathways including protein modification
Emphasized need for integration of toxicology with risk assessment frameworks

Abstract

This review synthesizes available in vitro, in vivo, mechanistic, and regulatory data on HCA and Lilial, examines plausible interaction pathways including electrophile-mediated protein modification and metabolic competition, and identifies key gaps requiring mixture-oriented investigation. Greater integration of mechanistic toxicology with cumulative risk assessment frameworks is needed to better reflect real-world co-exposure scenarios involving fragrance aldehydes.

اسأل الذكاء الاصطناعي

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