November 16, 2014JAMA
Extent, Location, and Clinical Significance of Non–Infarct-Related Coronary Artery Disease Among Patients With ST-Elevation Myocardial Infarction
Why the study?
Does the presence of obstructive non-infarct-related artery disease increase 30-day mortality in patients presenting with STEMI?
Population
Patients presenting with ST-elevation myocardial infarction from a pooled analysis of 8 clinical trials
Design
Meta-analysis
Follow-up
30 days
Authors
Discussion
Loading...
Member takes
Implication
May influence non-IRA revascularization decisions in STEMI; extends pooled-trial evidence on multivessel disease prognosis.
Structured PICO
Does the presence of obstructive non-infarct-related artery disease increase 30-day mortality in patients presenting with STEMI?
P
Population
Patients presenting with ST-elevation myocardial infarction (STEMI) from a pooled analysis of 8 clinical trials
I
Intervention
Presence of obstructive non-infarct-related artery (non-IRA) disease
O
Outcome
30-day mortalityhard clinical
Obstructive non-infarct-related artery disease is common in STEMI patients and is associated with a modest increase in 30-day mortality, raising questions about the optimal timing and appropriateness of non-IRA revascularization.
Limitations
- Retrospective design requiring confirmation in prospectively designed studies
Cite This Study
Park et al. (2014) studied this question.