November 16, 2014

Extent, Location, and Clinical Significance of Non–Infarct-Related Coronary Artery Disease Among Patients With ST-Elevation Myocardial Infarction

Structured PICO

Does the presence of obstructive non-infarct-related artery disease increase 30-day mortality in patients presenting with STEMI?

Population

Patients presenting with ST-elevation myocardial infarction (STEMI) from a pooled analysis of 8 clinical trials

Intervention

Presence of obstructive non-infarct-related artery (non-IRA) disease

Outcome

30-day mortalityhard clinical

Obstructive non-infarct-related artery disease is common in STEMI patients and is associated with a modest increase in 30-day mortality, raising questions about the optimal timing and appropriateness of non-IRA revascularization.

Abstract

In a retrospective pooled analysis of 8 clinical trials, obstructive non-IRA disease was common among patients presenting with STEMI, and was associated with a modest statistically significant increase in 30-day mortality. These findings require confirmation in prospectively designed studies, but raise questions about the appropriateness and timing of non-IRA revascularization in patients with STEMI.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Journals

JAMA

Institutions

Stanford University

University of Alberta

Duke Medical Center

References and Citations

Add This Paper to Your Research Feed

Any time a new paper drops it will be there.