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March 25, 2026Sexual MedicineOpen Access

Selective serotonin reuptake inhibitor and serotonin-norepinephrine reuptake inhibitor use and sexual dysfunction: a pharmacovigilance analysis

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Authors

MSMengting ShenLHLuyao HePCPei Chen

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Overview

Pharmacovigilance analysis examines sexual dysfunction in antidepressant users, suggesting tailored treatment options.

Key Points

  • The aim is to explore the link between SSRIs/SNRIs and specific sexual dysfunction symptoms.
  • Analyzed adverse events from the FDA's FAERS database.
  • Utilized reporting odds ratios and information components to detect adverse effects.
  • Employed Bayesian shrinkage transformation to reduce variability.
  • All SSRIs/SNRIs were associated with sexual dysfunction incidents in the database.
  • Sertraline showed the widest range of sexual dysfunction symptoms.
  • Duloxetine exhibited a more limited sexual adverse effect profile.

Cite This Study

Shen et al. (2026) studied this question.

synapsesocial.com/papers/69c37bb3b34aaaeb1a67e575https://doi.org/10.1093/sexmed/qfag008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Urinary and gynecologic adverse events associated with SSRI use2024
  2. 2Pharmacovigilance of SSRIs in Children and Adolescents withDepression: Disproportionality Analysis of Serotonin Adverse EventsUsing the FAERS Database2026
  3. 3Sexual Dysfunction Induced by Antidepressants—A Pharmacovigilance Study Using Data from VigiBaseTM2024 · 10 citations
  4. 4Sexual dysfunction associated with selective serotonin reuptake inhibitors in adults with depression: a systematic review and meta-analysis2026 · 7 citations
  5. 5Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System2024 · 8 citations