What question did this study set out to answer?

To evaluate the safety and efficacy of Yttrium-90 transarterial radioembolization (Y90-TARE) for treating fibrolamellar hepatocellular carcinoma (FL-HCC).

March 29, 2026Journal of Hepatocellular CarcinomaOpen Access

Utility of Yttrium-90 Radioembolization for the Treatment of Fibrolamellar Hepatocellular Carcinoma: A Tertiary Cancer Center Experience

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Authors

MKMohammad KhavandiThe University of Texas MD Anderson Cancer Center KAKevin AgahiThe University of Texas MD Anderson Cancer Center SLSunyoung LeeThe University of Texas MD Anderson Cancer Center

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Implication

Retrospective study demonstrates effective tumor control in fibrolamellar hepatocellular carcinoma patients through Y90-TARE, implying its potential role in treatment.

Key Points

To evaluate the safety and efficacy of Yttrium-90 transarterial radioembolization (Y90-TARE) for treating fibrolamellar hepatocellular carcinoma (FL-HCC).
Retrospective analysis of patients with FL-HCC treated with Y90-TARE
Assessment of treatment response using mRECIST guidelines at 1, 3, and 6 months
Evaluation of clinical outcomes and complications from electronic medical records
Median progression-free survival (PFS) was 9.0 months
Median overall survival (OS) was 15.8 months
Partial response observed in 86% of patients at 3 months and 100% at 6 months
Two patients successfully underwent surgery after treatment, one liver transplant and one hepatectomy
No grade 3 or greater adverse events reported within 30 days

Cite This Study

Khavandi et al. (2026) studied this question.

synapsesocial.com/papers/69c8c2fcde0f0f753b39d802 https://doi.org/10.2147/jhc.s546213

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Implication

Retrospective study demonstrates effective tumor control in fibrolamellar hepatocellular carcinoma patients through Y90-TARE, implying its potential role in treatment.

Utility of Yttrium-90 Radioembolization for the Treatment of Fibrolamellar Hepatocellular Carcinoma: A Tertiary Cancer Center Experience

Discussion

Member takes

Implication

Key Points

Cite This Study

Utility of Yttrium-90 Radioembolization for the Treatment of Fibrolamellar Hepatocellular Carcinoma: A Tertiary Cancer Center Experience

Discussion

Member takes

Implication

Key Points

Cite This Study

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