Key result
SCORE2-Diabetes outperforms ASCVD risk score for predicting cardiovascular events in Japanese patients with diabetes.
Why the study?
Prediction models identify patients with diabetes mellitus at high CVD risk, but no risk prediction models have been developed specifically for Japanese patients with diabetes mellitus.
Does the SCORE2-Diabetes model improve cardiovascular risk prediction compared to the ASCVD risk score in Japanese patients with diabetes mellitus?
Cohort (n=1,186)
No
Does the SCORE2-Diabetes model improve cardiovascular risk prediction compared to the ASCVD risk score in Japanese patients with diabetes mellitus?
Effect estimate: HR 1.09 (95% CI 1.05-1.14)
p-value: p=<0.001
Both ASCVD risk score and SCORE2-Diabetes are valid for predicting cardiovascular events in Japanese patients with diabetes, but SCORE2-Diabetes demonstrates superior predictive performance.
Supports preferential use of SCORE2-Diabetes over ASCVD in Japanese diabetes patients; extends validation to East Asian cohorts.
Diabetes mellitus is a major risk factor for cardiovascular disease (CVD), and prediction models are recommended to identify patients with diabetes mellitus at high CVD risk. However, no risk prediction models have been developed for Japanese patients with diabetes mellitus. Therefore, we aimed to validate the Atherosclerotic Cardiovascular Disease (ASCVD) risk score and Systematic Coronary Risk Evaluation 2-Diabetes (SCORE2-Diabetes) model in Japanese patients with diabetes mellitus.
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Singh et al. (2026) conducted a cohort in Diabetes Mellitus (n=1,186). SCORE2-Diabetes vs. ASCVD risk score was evaluated on Composite of myocardial infarction and stroke (HR 1.09, 95% CI 1.05-1.14, p=<0.001). SCORE2-Diabetes demonstrated superior predictive performance for cardiovascular events compared to the ASCVD risk score in Japanese patients with diabetes mellitus (AUROC 0.688 vs 0.639).
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