February 23, 2015Open Access

TNF- down-regulates sarcoplasmic reticulum Ca2+ ATPase expression and leads to left ventricular diastolic dysfunction through binding of NF- B to promoter response element

Structured PICO

Does simvastatin block the TNF-α-induced suppression of SERCA2a gene expression and subsequent left ventricular diastolic dysfunction?

Intervention

Simvastatin

Outcome

SERCA2a gene expression and left ventricular diastolic dysfunctionsurrogate

Simvastatin blocks the TNF-α-induced suppression of SERCA2a, suggesting a potential therapeutic role for statins in treating inflammation-related diastolic dysfunction.

Abstract

TNF-α suppresses SERCA2a gene expression via the IKK/IκB/NF-κB pathway and binding of NF-κB to the SERCA2a gene promoter, and its effect is blocked by simvastatin, demonstrating the potential therapeutic effect of statins in treating inflammation-related diastolic dysfunction.

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Cite This Study

Tsai et al. (Mon,) studied this question.

synapsesocial.com/papers/69d572c5d9840517963cd5ee https://doi.org/https://doi.org/10.1093/cvr/cvv008

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