Long-term prognostic significance of negative CT-derived fractional flow reserve in patients with stable CAD: A meta-analysis of reconstructed time-to-event data

Key Points

• This research aims to assess the long-term prognostic value of negative CT-derived fractional flow reserve in patients with stable coronary artery disease.
• Conducted a meta-analysis of reconstructed time-to-event data
• Included patients with stable coronary artery disease
• Analyzed rates of MACE-free survival
• Assessed the implications of CT-FFR >80
• Patients with CT-FFR >80 show high rates of long-term MACE-free survival
• Negative CT-FFR indicates lower need for invasive evaluations.
• Findings support safe deferral from interventions in selected patients.