Are cardiac troponin T (cTnT) concentrations falsely elevated due to assay cross-reaction in patients with skeletal myopathies?
cTnT is frequently elevated in patients with skeletal myopathies due to assay cross-reactivity, suggesting cTnI should be preferred for assessing true cardiac injury in these patients.
Measured cTnT concentrations were chronically elevated in the majority of patients with skeletal myopathies, whereas cTnI elevation was rare. Our data indicate that cross-reaction of the cTnT immunoassay with skeletal muscle troponin isoforms was the likely cause.
Schmid et al. (Sun,) studied this question.
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