Does EAT-derived miR-92a-3p improve the myocardial redox state in the human heart?
EAT-derived miR-92a-3p improves the myocardial redox state via the Wnt5a/Rac1/NADPH oxidase axis, representing a potential therapeutic target for obesity-related heart disease.
EAT-derived miRNAs exert paracrine effects on the human heart. Indeed miR-92a-3p suppresses the wingless-type MMTV integration site family, member 5a/Rac1/NADPH oxidase axis and improves the myocardial redox state. EAT-derived miR-92a-3p is related to improved clinical outcomes and is a rational therapeutic target for the prevention and treatment of obesity-related heart disease.
Carena et al. (Sat,) studied this question.